Before we talk testing, let’s talk about the HPV vaccine

Before you understand your human papillomavirus (HPV) and cervical cancer testing options, it’s important to know that getting the HPV vaccine is one of the best ways to prevent cervical cancer. HPV vaccination provides safe, effective, and long-lasting protection.1 Remember, screening remains important for cervical cancer prevention, even for women who have had the HPV vaccine.

Be proactive about your cervical health by learning about your testing options

Getting screened for HPV and cervical cancer is one of the most important things you can do for your health. All women above a certain age, even those in monogamous relationships or with the same long-term partner, need to be tested for HPV. A positive test result doesn't indicate when you got the infection or from whom, and some research suggests that HPV can lay dormant for some time.2 Testing positive is not a reflection on you, your partner or your lifestyle. So, while testing HPV positive doesn't necessarily mean you have, or will develop cervical cancer, it does mean you could be at an increased risk. It's important to know which HPV type you have to fully understand your risk.

Sharing information is a powerful way to build awareness around the topic of cervical cancer prevention. In the video below, Danielle shares her HPV and cervical cancer prevention story, in the hope that other women won't have to go through the same experience.

Watch Danielle Tell Her Story About HPV and Cervical Cancer Prevention

 

You can also visit Danielle's page to watch and read the rest of her journey to uncover the latest HPV screening and cervical cancer prevention technology.


Even if you received the HPV vaccine, you should still be screened for cervical cancer
. Although the available HPV vaccines cover some high-risk HPV types (including HPV 16 and HPV 18, the two highest risk types), they do not cover all high-risk HPV types. Therefore, experts still recommend that you continue to get screened regularly for cervical cancer even after you’ve received the vaccine.

Click here to view the full story of HPV vs. Pap for Cervical Screening

It’s time for a change, HPV and Pap screening are not the same.

For cervical cancer, there are primarily two types of screening tests that healthcare providers use today, the Pap test and/or the HPV test.

An HPV Test The Pap Test
  • More sensitive than the Pap test in detecting cervical disease (CIN3+)3

  • Checks for the presence of high-risk HPV, the cause of almost all cases of cervical cancer,4 even before changes to cervical cells occurs

  • Performed with molecular technology that is not subject to the varied interpretations of different laboratories

  • Misses fewer cervical cancer cases

  • Your doctor may recommend an HPV test even if you have already had the HPV vaccine5
  • Looks for abnormal changes in your cervical cells under a microscope6

  • Does not test for the presence of HPV infection7

  • Is a subjective interpretation of looking for abnormal cells under a microscope8

  • Results can vary from lab to lab

  • In women with disease, it may provide false reassurance of safety, since close to 30% of women with cancer received a normal test result9

The HPV Test

An HPV test detects the DNA of high-risk HPV at infection levels that have been demonstrated to cause high grade cervical disease or precancer. The sample needed for an HPV test is taken from the cervix by a healthcare provider the same way as a Pap test–which means you won't have to do anything different during your women's wellness exam to receive greater reassurance of your health. The sample is then sent to a lab to be tested for high-risk HPV on an automated instrument using molecular technology. HPV tests give an early, accurate look at your cervical cancer risk.

The Pap Test

The Pap test has been in use for around 80 years; it looks for abnormal cells growing on the cervix that can be early signs of cancer. A healthcare provider collects cell samples from your cervix and sends the sample to a laboratory for examination under a microscope by a trained professional. However, a normal Pap result does not always mean cancer free: up to one-third of cervical cancers occurred in women with a normal Pap.10,11

An HPV test vs. the Pap test: deciding what’s right for you

You and your healthcare provider can discuss which cervical cancer screening test is right for you. Medical guidelines offer different ways that the HPV and Pap tests can be used depending on a number of factors such as the patient’s age and medical history. Different countries will make decisions around guidelines specific to their local decision-making and implementation process.

In the U.S. it is recommended that women start cervical cancer screening at 21 years of age. Most health plans cover checkups, which would include a Pap test. In the U.S., the Affordable Care Act (ACA) encourages health plans to cover high-risk HPV testing for women who are 30 years of age and older in addition to the Pap test.

Guidelines example, U.S. - updates in development

Age Screening Recommendation
21 - 29 Pap test every 3 years
30 - 65 Pap test every 3 years OR
HPV test every 5 years OR
Co-testing (Pap and HPV test) every 5 years12

The cobas® HPV test

The cobas® HPV test is used in cervical cancer screening to determine a woman's risk of precancer or cancer. The test provides three results in one: individual results for HPV 16 and HPV 18, in addition to a pooled result for 12 other high-risk HPV types. Having immediate information about your risk of cervical cancer can help you and your doctor determine what next steps to take. The cobas® HPV test is the first test approved by the FDA to be used as a first-line primary screening test for cervical cancer in women ages 25-65.

The sample collection process for the cobas® HPV test is exactly the same as it is for the Pap test. Your healthcare provider will use an instrument called a speculum to look into your vagina. Another device is then inserted to collect cell samples from the cervix. The samples are placed in a vial containing preservative fluid and sent to a laboratory for the HPV test.

To request the cobas® HPV test, simply ask your healthcare provider at your next visit to your clinic.

Understanding Colposcopy

Depending on your HPV or Pap test result, you may be asked to come back later for repeat testing, or your healthcare provider may request more tests be run on your sample to further determine your risk for cervical disease. It may also be recommended that you come back for a colposcopy, to examine your cervix more closely. A colposcopy is an important step toward prevention after receiving abnormal test results. During a colposcopy, a doctor uses a colposcope (a lighted magnifying device) to see problems in the cervix that would be missed by the naked eye. A tissue sample or cervical biopsy may also be taken for laboratory analysis to determine if there are cellular changes indicating cervical precancer or cancer. After the procedure, it is normal to feel some soreness and have some vaginal bleeding or discharge.

Know Your Risk for Cervical Cancer Facebook Community

Openly talking about HPV helps to make the topic less of a taboo.

 

Know Your Risk for Cervical Cancer is a Facebook community dedicated to increasing women’s awareness and knowledge about HPV, its role in cervical cancer, the importance of screening tests, and connecting with other women. Join our community of over 67,000 individuals dedicated to encouraging each other to be in control of their own health and wellness.

 

 

Ready to take action for your cervical health? Our 30-day challenge card will help guide you.  

Learn More

  1. Centers for Disease Control and Prevention. Reasons to get vaccinated. Retrieved from https://www.cdc.gov/hpv/parents/vaccine/six-reasons.html (accessed 21 May 2020).
  2. Rositch AF, Burke AE, Viscidi RP, Silver MI, Chang K, Gravitt PE. Contributions of Recent and Past Sexual Partnerships on Incident Human Papillomavirus Detection: Acquisition and Reactivation in Older Women. Cancer Res. 2012;72(23):6183–90.
  3. Wright TC, Stoler MH, Behrens CM, Sharma A, Zhang G, Wright TL. Primary cervical cancer screening with human papillomavirus: End of study results from the ATHENA study using HPV as the first-line screening test. Gynecol Oncol.2015;136(2):189–97.
  4. Walboomers JMM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathology. 1999;189(1):12–9.
  5. Centers for Disease Control and Prevention. HPV vaccine information for young women January 2017. Available at: https://www.cdc.gov/std/hpv/stdfact-hpv-vaccine-young-women.htm (accessed 21 May 2020).
  6. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/pap-test (accessed 13 January 2021).
  7. https://www.cancer.org/cancer/cancer-causes/infectious-agents/hpv/hpv-and-hpv-testing.html (accessed 11 January 2021).
  8. Singer A, Monaghan JM, Quek SC, Deery ARS. Lower genital precancer: colposcopy, pathology and treatment. 2nd edition. Blackwell Science; 2000
  9. Sung H, Kearney KA, Miller M, Kinney W, Sawaya GF, Hiatt RA. Papanicolaou smear history and diagnosis of invasive cervical carcinoma among members of a large prepaid health plan. Cancer. 2000;88(10):2283–9.
  10. Leyden WA, Manos MM, Geiger AM, Weinmann S, Mouchawar J, Bischoff K, et al. Cervical Cancer in Women With Comprehensive Health Care Access: Attributable Factors in the Screening Process. Jnci J National Cancer Inst. 2005;97(9):675–83.
  11. Andrae B, Kemetli L, Sparén P, Silfverdal L, Strander B, Ryd W, et al. Screening-Preventable Cervical Cancer Risks: Evidence From a Nationwide Audit in Sweden. Jnci J National Cancer Inst. 2008;100(9):622–9.
  12. U.S. Preventive Services Task Force. Final Recommendation Statement, Cervical Cancer: Screening. Retrieved from https://www.uspreventiveservicestaskforce.org/Page/Document/UpdateSummaryFinal/cervical-cancer-screening2 (accessed 21 May 2020).